Butein up-regulates the expression of the π class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathway.

@article{Chang2010ButeinUT,
  title={Butein up-regulates the expression of the π class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathway.},
  author={Hebron Chun-Wei Chang and H P Chen and Hui-shan Tung and Kai-Li Liu and Chia-Wen Tsai and C D Lii},
  journal={Journal of agricultural and food chemistry},
  year={2010},
  volume={58 16},
  pages={8994-9000}
}
Induction of phase II enzymes is an important mechanism of chemoprevention. Here we compared the effects of chalcones on the expression of the π class of glutathione S-transferase (GSTP) in rat primary hepatocytes. Hepatocytes were treated with 10 or 25 μM of phloretin or butein for 24 h. Both butein and phloretin dose-dependently increased GSTP protein expression, and the induction potency of butein was stronger than that of phloretin. The increase in GSTP mRNA in cells treated with 25 μM of… CONTINUE READING