Butea monosperma and chemomodulation: protective role against thioacetamide-mediated hepatic alterations in Wistar rats.

@article{Sehrawat2006ButeaMA,
  title={Butea monosperma and chemomodulation: protective role against thioacetamide-mediated hepatic alterations in Wistar rats.},
  author={Anuradha Sehrawat and Tajdar Hussain Khan and L. Sivarama Prasad and Sarwat Sultana},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2006},
  volume={13 3},
  pages={157-63}
}
The present study was carried out to study the effect of Butea monosperma, a known liver acting drug on the tumor promotion related events of carcinogenesis in rat liver. Thioacetamide (TAA) was used to induce tumor promotion response and oxidative stress and caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in malondialdehyde (MDA) formation, hydrogen peroxide (H(2)O(2)) generation, ornithine decarboxylase (ODC) activity and unscheduled… CONTINUE READING

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