Busulfan use in hematopoietic stem cell transplantation: pharmacology, dose adjustment, safety and efficacy in adults and children.

@article{Krivoy2008BusulfanUI,
  title={Busulfan use in hematopoietic stem cell transplantation: pharmacology, dose adjustment, safety and efficacy in adults and children.},
  author={Norberto Krivoy and Erica Hoffer and Yael Lurie and Yedidia Bentur and Jacob M. Rowe},
  journal={Current drug safety},
  year={2008},
  volume={3 1},
  pages={60-6}
}
Busulphan (1, 4-bis [methanesulfonyl-y] butane) is a bi-functional alkylating agent that, in combination with cyclophosphamide, has been commonly used in conditioning regimens before hematological stem cell transplantation (HSCT) for nearly 20 years. Busulfan has a very narrow therapeutic index, and acute toxicity may be related to absorption and disposition of the drug and metabolites. Precise delivery of the oral formulation is compromised by erratic gastrointestinal absorption, particularly… CONTINUE READING

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