Busulfan therapy of central nervous system xenografts in athymic mice

  title={Busulfan therapy of central nervous system xenografts in athymic mice},
  author={R. Aaron and G. Elion and O. Colvin and M. Graham and Steven Keir and D. Bigner and H. Friedman},
  journal={Cancer Chemotherapy and Pharmacology},
  • R. Aaron, G. Elion, +4 authors H. Friedman
  • Published 2004
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • We evaluated the antitumor activity of busulfan against a panel of tumor cell lines and xenografts in athymic nude mice derived from childhood high-grade glioma, adult high-grade glioma, ependymoma, and medulloblastoma. Busulfan displayed similar activity against a panel of four medulloblastoma cell lines (D283 Med, Daoy, D341 Med, and D425 Med) and four corresponding sublines with laboratory-generated or clinically acquired resistance to 4-hydroperoxycyclophosphamide [D283 Med (4-HCR), Daoy (4… CONTINUE READING
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