Busulfan pharmacokinetics using a single daily high-dose regimen in children with acute leukemia.

Abstract

The pharmacokinetics of busulfan, given as a single daily dose (either 4 mg/kg or 150 mg/m2), was determined in 22 children undergoing bone marrow transplantation for acute leukemia. The single daily dose regimen showed similar pharmacokinetics to previously reported regimens of 4 x 1 mg/kg, except for fourfold higher mean peak plasma levels and negligible… (More)

Cite this paper

@article{Shaw1994BusulfanPU, title={Busulfan pharmacokinetics using a single daily high-dose regimen in children with acute leukemia.}, author={P J Shaw and C E Scharping and Robin Brian and J W Earl}, journal={Blood}, year={1994}, volume={84 7}, pages={2357-62} }