Busulfan in hematopoietic stem cell transplant setting.

@article{McCune2009BusulfanIH,
  title={Busulfan in hematopoietic stem cell transplant setting.},
  author={Jeannine McCune and Leona A Holmberg},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2009},
  volume={5 8},
  pages={957-69}
}
This paper focuses primarily on the data published in the last decade about the pharmacokinetics and pharmacodynamics of oral and intravenous (i.v.) busulfan, therapeutic drug monitoring and clinical outcome in hematopoietic stem cell transplant (HCT) patients. Busulfan is commonly used in HCT as it is toxic to the marrow. Busulfan is available as oral or i.v. formulation. The most common significant toxicity of busulfan is sinusoidal obstruction syndrome. Even with the introduction of i.v… CONTINUE READING

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