Busulfan disposition in children.

@article{Grochow1990BusulfanDI,
  title={Busulfan disposition in children.},
  author={LouiseB. Grochow and William Krivit and Chester B. Whitley and B. B. Blazar},
  journal={Blood},
  year={1990},
  volume={75 8},
  pages={
          1723-7
        }
}
Children receive busulfan orally as part of myeloablative therapy before bone marrow transplantation for malignant and nonmalignant conditions. Children have been reported to have a low incidence of severe toxicity and significant rates of failure to achieve full engraftment. We evaluated the disposition of busulfan in children between 2 months and 3.6 years of age with lysosomal storage diseases, leukemia, and immunodeficiency disorders receiving oral doses of 1 or 2 mg/kg using a gas… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 63 CITATIONS, ESTIMATED 68% COVERAGE

Up-regulation of glutathione S-transferase activity in enterocytes of young children.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 1999
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1991
2018

CITATION STATISTICS

  • 1 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Lysosomal storage diseases treated by bone marrow transplantation: Review of 21 patients, in Johnson L, Pochedly C (eds): Bone Marrow Transplantation in Children

W Krivit, CB Whitley, +4 authors B Blazar
  • 1990

Metabolism of14C-busulfan in isolated perfused rat liver

  • European Journal of Drug Metabolism and Pharmacokinetics
  • 1987