Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial.

  title={Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial.},
  author={A. McRae-Clark and N. Baker and K. Gray and T. Killeen and A. Wagner and K. Brady and C. L. DeVane and Jessica Norton},
  journal={Drug and alcohol dependence},
  • A. McRae-Clark, N. Baker, +5 authors Jessica Norton
  • Published 2015
  • Medicine
  • Drug and alcohol dependence
  • BACKGROUND The purpose of this study was to evaluate the efficacy of buspirone, a partial 5-HT1A agonist, for treatment of cannabis dependence. METHODS One hundred seventy-five cannabis-dependent adults were randomized to receive either up to 60mg/day of buspirone (n=88) or placebo (n=87) for 12 weeks combined with a brief motivational enhancement therapy intervention and contingency management to encourage study retention. Cannabis use outcomes were assessed via weekly urine cannabinoid… CONTINUE READING
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