• Medicine
• Published in Drug and alcohol dependence 2015
• DOI:10.1016/j.drugalcdep.2015.08.013

Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial.

@article{McRaeClark2015BuspironeTO,
  title={Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial.},
  author={Aimee L. McRae-Clark and Nathaniel L. Baker and Kevin M. Gray and Therese K. Killeen and Amanda Marie Wagner and Kathleen T. Brady and C Lindsay DeVane and Jessica Norton},
  journal={Drug and alcohol dependence},
  year={2015},
  volume={156},
  pages={
          29-37
        }
}

• Aimee L. McRae-Clark, Nathaniel L. Baker, +5 authors Jessica Norton

BACKGROUND The purpose of this study was to evaluate the efficacy of buspirone, a partial 5-HT1A agonist, for treatment of cannabis dependence. METHODS One hundred seventy-five cannabis-dependent adults were randomized to receive either up to 60mg/day of buspirone (n=88) or placebo (n=87) for 12 weeks combined with a brief motivational enhancement therapy intervention and contingency management to encourage study retention. Cannabis use outcomes were assessed via weekly urine cannabinoid… CONTINUE READING

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