Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans.

@article{Coccaro1990BuspironeCP,
  title={Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans.},
  author={Emil F. Coccaro and Susan M. Gabriel and Larry J. Siever},
  journal={Psychopharmacology bulletin},
  year={1990},
  volume={26 3},
  pages={393-405}
}
The prolactin (PRL) response to challenge with buspirone hydrochloride, a serotonin1a (5-HT1a) receptor agonist, was examined in 5 healthy male volunteers and in 10 healthy male and female patients with primary DSM-III personality disorder. In healthy volunteers, pretreatment with the nonselective 5-HT receptor antagonist, metergoline (4 mg p.o.) completely… CONTINUE READING