Buspirone and related compounds as alternative anxiolytics

@article{Taylor1991BuspironeAR,
  title={Buspirone and related compounds as alternative anxiolytics},
  author={Duncan P. Taylor and S. Moon},
  journal={Neuropeptides},
  year={1991},
  volume={19},
  pages={15-19}
}
The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemical homology with the benzodiazepines. This presentation reviews the efficacy of buspirone (BuSpar), the first of this class to reach wide acceptance, and its analogs, gepirone… Expand
Anxiolytic effects of drugs acting on 5-HT receptor subtypes
Anxiolytic effects have been well documented for the 5-HTIApartial agonist azapirones (e.g. buspirone). Benzodiazcpines (which have indirect serotonergic actions) continue to be more widelyExpand
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TLDR
The plus-maze profile observed with flesinoxan is very similar to that previously reported for 8-OH-DPAT in the same test but, despite superficial similarities, can be distinguished from that seen with buspirone. Expand
Preclinical pharmacology of B-20991, a 5-HT1A receptor agonist with anxiolytic activity.
TLDR
The results suggest that B-20991 is a 5-HT1A receptor agonist that exhibits anxiolytic activity that causes a dose-related increase in the social interaction and light/dark box behavioral scores. Expand
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TLDR
5-HT1A partial agonists as adjunctive therapy improved overall psychopathology with a trend to improve positive symptoms in patients with schizophrenia. Expand
Azapirones for the treatment of anxiety – an overview
Anxiety disorders belong to the most common psychiatric diagnosis. Over the years, benzodiazepines were considered the gold standard for pharmacological treatment of anxiety. They are effectiveExpand
Behavioural Effects in Mice of Subchronic Buspirone, Ondansetron and Tianeptine. II. The Elevated Plus-Maze
TLDR
Results show that subchronic treatment with ondansetron failed to influence the behaviour of mice in the plus-maze, while the limited changes induced by buspirone could not be attributed to anxiety-related processes. Expand
Profile of action of 5-HT3 receptor antagonists, ondansetron and WAY 100289, in the elevated plus-maze test of anxiety of mice
TLDR
It is suggested that the large within- and between-test variability observed with these compounds may indicate an action on mechanisms other than anxiety, as well as the enigmatic effects of 5-HT3 receptor antagonists in animal models of anxiety. Expand
Behavioural Effects in Mice of Subchronic Buspirone, Ondansetron and Tianeptine. I. Social Interactions
TLDR
The apparent anxiogenic effect of tianeptine is a novel finding which requires further study, while ondansetron had no effect on the categories of behaviour and failed to induce an anxiolytic-like enhancement of social investigation. Expand
Blockade of the anxiolytic-like action of ipsapirone and buspirone, but not that of 8-OH-DPAT, by adrenalectomy in male rats
TLDR
Data suggest that adrenocortical secretions play a role in the anxiolytic-like actions of buspirone and ipsapirone, but not in those of 8-OH-DPAT, and that adrenaline may be participating in the action of these compounds on the burying behavior latency. Expand
In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response
TLDR
Despite the significant effect on growth hormone and body temperature, a clinical dose of tandospirone had a negligible effect on [11C]WAY 100635 binding, which indicates that the agonist produces a pharmacological effect without measurable occupancy, and a new index other than occupancy will be required for the in vivo evaluation of agonists. Expand
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TLDR
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