Buspirone Versus Methylphenidate in the Treatment of Attention Deficit Hyperactivity Disorder: A Double-Blind and Randomized Trial

  title={Buspirone Versus Methylphenidate in the Treatment of Attention Deficit Hyperactivity Disorder: A Double-Blind and Randomized Trial},
  author={Rozita Davari-Ashtiani and Mahin Eslami Shahrbabaki and Katayoon Razjouyan and Homayoun Amini and Homa Mazhabdar},
  journal={Child Psychiatry \& Human Development},
The efficacy and side effects of buspirone compared with methylphenidate (MPH) in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). A total of 34 children with ADHD as defined by DSM-IV-TR were randomized to buspirone or methylphenidate dosed on weight-adjusted basis at buspirone (0.5 mg/kg/day) and methylphenidate (0.3–1 mg/kg/day) for a 6-week double-blind clinical trial. The principle measures of outcome were the teacher and parent ADHD Rating Scale. The side… 
Buspirone versus methylphenidate in the treatment of children with attention- deficit/ hyperactivity disorder: randomized double-blind study.
Assessment of the efficacy of buspirone in the treatment of children with ADHD compared to methylphenidate in a double blind, randomized clinical trial suggests that administration of busPirone was less effective than methyl phenidate in the Treatment of ADHD.
Comparison of the effects of methylphenidate and the combination of methylphenidate and risperidone in preschool children with attention-deficit hyperactivity disorder
Risperidone and methylphenidate may be effective and well tolerated in preschool children with ADHD, and adding ris peridone to methylphenidone may decrease the occurrence of some side effects of methyl phenidate such as insomnia and anorexia.
Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies.
A systematic review of randomised clinical trials (RCTs) for methylphenidate treatment for children and adolescents with ADHD demonstrated no increase in serious adverse events, but a high proportion of participants suffered a range of non-serious adverse events.
Current Literature in ADHD
A recent pilot study examined sequential treatment with methylphenidate with the later addition of Fluvoxamine, an SSRI antidepressant. Children with ADHD and anxiety were first titrated to an
Efficacy and safety of drugs for attention deficit hyperactivity disorder in children and adolescents: a network meta-analysis
Network meta-analysis offered a broader overview on the available treatments for ADHD, especially for safety issues, and contributes towards evidence gathering and clinical practice decisions.
Comparative Study of Treatments of Children with ADHD with Medication Alone Vs Medication with Cognitive Behavioral Therapy
Clinical trials with zinc and magnesium+B6 have shown to yield positive results in lowering the ADHD symptoms, however, further study is needed to factor in bioavailability, efficacy of other dosages, diet, and any other factors that could hinder the function of the dietary supplements internally.
Methylphenidate increases the urinary excretion of vanillylmandelic acid in rats that is attenuated by buspirone co-administration.
This study found significant (P<0.01) raised urinary VMA excretion in methylphenidate group however significant reduction in VMA levels were seen after buspirone co-administration, which could be helpful to increase the clinical use ofethylphenidate in the treatment of different disoders.
A pilot study on the efficacy of Valeriana officinalis mother tincture and Valeriana officinalis 3X in the treatment of attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is an increasingly prevalent behavioural disorder characterised by inattention, impulsivity and hyperactivity.  Valeriana officinalis is a botanical
The Effectiveness of Medicinal and Non-medicinal Treatments of Attention-Deficit/Hyperactivity Disorder
The effectiveness of multiple treatment methods commonly used for this disorder as well as issues concerning the effects and over-prescription of stimulant medications has become more prominent in recent years and should be further discussed.
Buspirone in Children and Adolescents with Anxiety: A Review and Bayesian Analysis of Abandoned Randomized Controlled Trials.
A Bayesian approach is presented and validated for the reanalysis of summary data in abandoned clinical trials and available pharmacokinetic, tolerability, and efficacy data from two large, randomized controlled trials of buspirone in pediatric patients with generalized anxiety disorder are reviewed.


An open clinical trial of buspirone in children with attention-deficit/hyperactivity disorder.
  • S. Malhotra, P. Santosh
  • Medicine, Psychology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 1998
Buspirone showed a favorable side effect profile and significantly reduced the symptoms of ADHD, and appears equally effective in improving the varied symptoms of the disorder.
A controlled study of nortriptyline in children and adolescents with attention deficit hyperactivity disorder.
Data suggest that NT is effective in reducing symptoms not only of ADHD but also of oppositionality, and this group of children and adolescents tolerated robust dosing of NT well, with few clinical or cardiovascular adverse events.
Venlafaxine in adults with attention-deficit/hyperactivity disorder: an open clinical trial.
Venlafaxine may be a promising agent for the treatment of ADHD in adults and controlled clinical trials are needed to further examine this issue.
Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial.
The results of this long-term, placebo-controlled study of the central stimulant amphetamine in the treatment of ADHD indicate that there are remaining positive effects of the drug 15 months after starting treatment.
Side effects of methylphenidate and desipramine alone and in combination in children.
Nausea, dry mouth, and tremor were present in at least twice as many children on combined methylphenidate and desipramine compared with any other condition and Clinically, side effects present during combined medication appeared to be similar to and no more serious than those associated with desipramsine alone.
Methyiphenidate vs. amphetamine: Comparative review
This article compares the two most common medications for Attention-Deficit/Hyperactivity Disorder (ADHD), using data from controlled studies. Medline and Psychinfo searches were done for 1984-1996
Methylphenidate and growth in hyperactive children. A controlled withdrawal study.
The results document a linkage between exposure to methylphenidate and reduction in growth velocity, however, they do not address whether the medication has long-term effects on height.
Association of attention-deficit disorder and the dopamine transporter gene.
Attention-deficit hyperactivity disorder (ADHD) has been shown to be familial and heritable, in previous studies. As with most psychiatric disorders, examination of pedigrees has not revealed a
An open trial of buspirone in the treatment of attention‐deficit disorder
The use of buspirone was studied as an alternative because of its longer excretion half‐life, decreased sedative side effects and more selective binding profile.
The stimulants.
Clinical guidelines for the management of children and adolescents receiving stimulants are offered, and treatment strategies are delineated for ADHD subjects with comorbidity and medication-induced adverse effects.