Buspirone, but not sumatriptan, induces miosis in humans: Relevance for a serotoninergic pupil control

@article{Fanciullacci1995BuspironeBN,
  title={Buspirone, but not sumatriptan, induces miosis in humans: Relevance for a serotoninergic pupil control},
  author={Marcello Fanciullacci and Riccardo Sicuteri and Massimo Alessandri and Pierangelo Geppetti},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1995},
  volume={57}
}

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The results suggest that measurement of pupil size may be a useful biomarker for predicting the pharmacodynamics of new 5-HT1A receptor agonists.

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The light-dependence of the miosis indicates that the 5-HT1A receptor agonists can modulate the light reflex, possibly via the noradrenergic control of central cholinergic neurones in the Edinger-Westphal nucleus.

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The plausibility of the serotonergic singultus hypothesis is examined against available pharmacokinetic, pharmacodynamic, and clinical data for a number of drugs; beneficial (therapeutic) effects for hiccup are to be expected from serotonin (5-HT) receptor subtype ligands that enhance vagal activity.

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The results for 8-OH-DPAT and possibly flexinoxan indicate the presence of a secretion-stimulating 5-HT1A receptor in monkey ciliary epithelium that has little effect on IOP.

Mirtazepine Overdose and Miosis

TLDR
The impression that mirtazepine in overdose is not lifethreatening is strengthened, as both cases had a benign outcome, and the blockade of the 5HT2 and 5HT3 receptors indirectly enhances 5HT1 actions, and this may explain how mirtzepine ingestion causes miosis.

Hyperthermia and Serotonin: The Quest for a “Better Cyproheptadine”

  • G. Petroianu
  • Biology
    International journal of molecular sciences
  • 2022
TLDR
Based on the theoretical model presented the “ideal” antidote against serotonin syndrome hyperthermia appears to be an antagonist at the 5-HT receptor sub types 2, 4 and 6 and an agonist at the receptor subtypes 1, 3 and 7.

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