Business: The billion-dollar biotech

@article{Dolgin2015BusinessTB,
  title={Business: The billion-dollar biotech},
  author={Elie S Dolgin},
  journal={Nature},
  year={2015},
  volume={522},
  pages={26-28}
}
Moderna Therapeutics has big ambitions and a bankroll to match. How a fledgling start-up became one of the most highly valued private drug firms ever. 
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Nanotechnology-Based Weapons: A Potential Approach for COVID-19
TLDR
The present review particularly emphasizes the perception of several nanoformulation-based approaches as an appropriate means to safeguard mankind against COVID-19.
Introduction to RNA Vaccines.
TLDR
In this chapter, key developments in RNA vaccines are reviewed and the contents of this volume of Methods in Molecular Biology are outlined.
Alternative strategies in cardiac preclinical research and new clinical trial formats
TLDR
This work examines recent gold standard randomized clinical trials and presents possible modifications to increase lead candidate throughput: adaptive designs, master protocols and drug repurposing.
Recent Progress in Nanotechnology for COVID-19 Prevention, Diagnostics and Treatment
TLDR
This review article comprehensively discusses the use of nanotechnology for COVID-19 based on three main categories: prevention, diagnostics and treatment and critically review the benefits of nanomaterials along with their applications in personal protective equipment, vaccine development, diagnostic device fabrication and therapeutic approaches.
Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic
TLDR
Nanoimmunity by design can help to design materials for immune modulation, either stimulating or suppressing the immune response, which would find applications in the context of vaccine development for SARS-CoV-2 or in counteracting the cytokine storm, respectively.
mRNA-Based Genetic Reprogramming.
ER Intrabodies: Potent Molecules for Specific Knockdown of Proteins Passingthe ER
A very promising protein knockdown technique is based on recombinant antibody fragments expressed inside the ER (ER intrabodies). ER intrabodies mediate inhibition of the function of proteins passing…
Single domain antibodies for the knockdown of cytosolic and nuclear proteins
  • T. Böldicke
  • Biology, Chemistry
    Protein science : a publication of the Protein Society
  • 2017
TLDR
The development of new endosomal escape protein domains and cell‐penetrating peptides for efficient transfection broaden the application of inhibiting sdAbs, and the generation of relatively new cell‐specific nanoparticles such as polymersomes and polyplexes carrying cytosolic/nuclear sdAb‐DNA or –protein will pave the way to apply cytosol/ nuclear sdAbs for inhibition of viral infection and cancer in the clinic.
Single domain antibodies for the knockdown of cytosolic and nuclear proteins.
TLDR
The development of new endosomal escape protein domains and cell-penetrating peptides for efficient transfection broaden the application of inhibiting sdAbs, and the generation of relatively new cell-specific nanoparticles such as polymersomes and polyplexes carrying cytosolic/nuclear sdAb-DNA or -protein will pave the way for inhibition of viral infection and cancer in the clinic.
ER-targeted Intrabodies Mediating Specific In Vivo Knockdown of Transitory Proteins in Comparison to RNAi
TLDR
Specificity and off-target effects (OTE) of these molecules as well as the therapeutic potential of ER intrabodies and RNAi have been compared.
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