Bursting noise in gene expression dynamics: linking microscopic and mesoscopic models

@article{Lin2015BurstingNI,
  title={Bursting noise in gene expression dynamics: linking microscopic and mesoscopic models},
  author={Yen Ting Lin and Tobias Galla},
  journal={Journal of the Royal Society Interface},
  year={2015},
  volume={13}
}
  • Y. LinT. Galla
  • Published 3 August 2015
  • Computer Science
  • Journal of the Royal Society Interface
The dynamics of short-lived mRNA results in bursts of protein production in gene regulatory networks. We investigate the propagation of bursting noise between different levels of mathematical modelling and demonstrate that conventional approaches based on diffusion approximations can fail to capture bursting noise. An alternative coarse-grained model, the so-called piecewise deterministic Markov process (PDMP), is seen to outperform the diffusion approximation in biologically relevant parameter… 

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