Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory

  title={Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory},
  author={Stephen W. Martin and Christopher C. Goodnow},
  journal={Nature Immunology},
The basis of immune memory leading to heightened secondary antibody responses is a longstanding unanswered issue. Here we show that a single irreversible molecular change in the B cell antigen receptor, which is brought about by immunoglobulin M (IgM) to IgG isotype switching, is sufficient to greatly increase the extrafollicular proliferative burst of antigen-specific B cells. The unique membrane-spanning regions of IgG do not alter the T cell–dependent activation and proliferation of antigen… CONTINUE READING

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