Burst and Tonic Spinal Cord Stimulation Differentially Activate GABAergic Mechanisms to Attenuate Pain in a Rat Model of Cervical Radiculopathy

@article{Crosby2015BurstAT,
  title={Burst and Tonic Spinal Cord Stimulation Differentially Activate GABAergic Mechanisms to Attenuate Pain in a Rat Model of Cervical Radiculopathy},
  author={Nathan D. Crosby and Christine L. Weisshaar and Jenell R. Smith and Martha E. Zeeman and Melanie D. Goodman-Keiser and Beth Winkelstein},
  journal={IEEE Transactions on Biomedical Engineering},
  year={2015},
  volume={62},
  pages={1604-1613}
}
Objective: Spinal cord stimulation (SCS) is widely used to treat neuropathic pain. Burst SCS, an alternative mode of stimulation, reduces neuropathic pain without paresthesia. However, the effects and mechanisms of burst SCS have not been compared to conventional tonic SCS in controlled investigations. This study compares the attenuation of spinal neuronal activity and tactile allodynia, and the role of γ-aminobutyric acid (GABA) signaling during burst or tonic SCS in a rat model of cervical… CONTINUE READING
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Are 10 kHz Stimulation and Burst Stimulation Fundamentally the Same?

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