Burning issues in the meta-analysis of pharmaceutical trials for depression.

  title={Burning issues in the meta-analysis of pharmaceutical trials for depression.},
  author={Konstantinos N Fountoulakis and Myrto T Samara and Melina Siamouli},
  journal={Journal of psychopharmacology},
  volume={28 2},
During the last decade a number of meta-analytic studies have been published and they triggered a debate on the true clinical usefulness of antidepressants. The current article comments on problems within the randomized controlled trials design, the study samples, the psychometric scales, the methods of meta-analysis, the interpretation of the results, and the reporting of conflicts of interest. Although the meta-analyses published so far agree that medication works in severe depression, they… CONTINUE READING
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