Burning Down the House: Cellular Actions during Pyroptosis

@inproceedings{LaRock2013BurningDT,
  title={Burning Down the House: Cellular Actions during Pyroptosis},
  author={Christopher N LaRock and Brad T. Cookson},
  booktitle={PLoS pathogens},
  year={2013}
}
Under threat of pathogen invasion, timely initiation of inflammation is a critical first step in generating a protective immune response. One major obstacle for the immune system is discriminating pathogenic microbes from non-pathogenic microbiota. Some members of the nucleotide-binding oligomerization domain-like receptor (NLR) family of pattern recognition receptors accomplish this distinction based on localization—typically, only pathogens deliver NLR ligands into the cytosol, where these… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 12 times over the past 90 days. VIEW TWEETS