Burnet Oration: Living in the Burnet lineage

  title={Burnet Oration: Living in the Burnet lineage},
  author={Peter C. Doherty},
  journal={Immunology and Cell Biology},
  • P. Doherty
  • Published 1 April 1999
  • Biology, Medicine
  • Immunology and Cell Biology
Scientific discoveries are not made in isolation. Innovation depends on resources, both intellectual and physical. A primary requirement is the development and maintenance of appropriate institutions. Such structures do not emerge by chance, but arise from opportunity, political will and the continued efforts and commitment of many people over long periods. Suitable buildings, laboratories and state‐of‐the‐art equipment are obviously necessary, but hardware alone is of little value in the… 
4 Citations
Burnet, chick embryos, viruses, clones and quantitative biology
  • P. Doherty
  • Biology, Medicine
    Immunology and cell biology
  • 2008
The great majority of FM Burnet’s working life was concerned with understanding and countering infectious processes. He was a meticulous experimentalist, with his 30 or more years as a bench
The bacteriophage, its role in immunology: how Macfarlane Burnet's phage research shaped his scientific style.
  • N. Sankaran
  • Biology, Medicine
    Studies in history and philosophy of biological and biomedical sciences
  • 2010
Evidence from Burnet's published work, as well as personal papers from the period he worked on the phages, demonstrates the direct impact that his experiments with phages had on the development of his characteristic scientific style and approaches, which manifested themselves in his later career and theories.
Challenged by complexity: my twentieth century in immunology.
  • P. Doherty
  • Medicine
    Annual review of immunology
  • 2007
It was there in 1973 that Rolf Zinkernagel and I discovered MHC I-restricted CD8(+) T cell recognition, a finding that led to the 1996 Nobel Prize for Physiology or Medicine.
Accessing complexity: the dynamics of virus-specific T cell responses.
Analysis to date with both naturally acquired and experimentally induced infections has established that the numbers of virus-specific CD8(+) T cells present during both the acute and memory phases of the host response are more than tenfold in excess of previously suspected values.


Howard Florey. Penicillin and after
surprisingly, this high-resolution history, which focuses more often than not on the practice of science rather than on science as a system of thought, has produced several new explanatory models:
Changing Patterns: An Atypical Autobiography
In this book the explosive growth and development of biology in the 20th century is seen through the eyes and mind of one of its principal and sometimes controversial actors.
Frank Macfarlane Burnet, 3 September 1899 - 31 August 1985
  • F. Fenner
  • Biology, Medicine
    Biographical Memoirs of Fellows of the Royal Society
  • 1987
Frank Macfarlane Burnet was the greatest biologist that Australia has produced and proposed two concepts in immunology, acquired immunological tolerance and the clonal selection theory of antibody production, that led to a more complete understanding of immune processes.
Howard Florey, the making of a great scientist
or the immune system. On the other hand, Baumel provides a clear, short history of genetics and of the work¬ ing-out of the fundamental role of DNA in the hereditary process. He also concisely
History of microbiology in Australia
The Noble Lectures in Immunology
A series of senior reviews highlighting some of the foundations on which the present-day science of immunology rests is published, including Gene cloning, the determination of the fundamental processes involved in the generation of T-cell receptor and immunoglobulin gene diversity, identification and characterization of a variety of signal substances in the immune system.
This chapter focuses on immunological surveillance, the concept that a major function of the immunological mechanisms in mammals is to recognize and eliminate foreign patterns arising in body by somatic mutation or some equivalent process.
The neutralization of animal viruses. II. A critical comparison of hypotheses.
It is shown that the discriminatory tests listed in support of the nondissociation hypothesis by Dulbecco et al. are, for the most part, inconclusive as their results are confounded with the systematic errors of the assay technique; the remainder directly contradicts their hypothesis.
The Neutralization of Animal Viruses
A model of neutralization based on the law of mass action is accepted as working hypothesis and the quantal assay system of influenza virus multiplying in surviving bits of the allantois is shown to be suited to the quantitative study ofneutralization.
A new analysis of allogeneic interactions.
A model of cell interaction is produced which will account for reactivity is much higher between different strains within a species than between species, in spite of the much greater antigenic disparity in the second case, and a very high proportion of cells may respond to allogeneic stimuli.