Burn wound γδ T-cells support a Th2 and Th17 immune response.

  title={Burn wound γδ T-cells support a Th2 and Th17 immune response.},
  author={M Rita Hepsi Rani and Qiong Zhang and Martin G. Schwacha},
  journal={Journal of burn care & research : official publication of the American Burn Association},
  volume={35 1},
Major burn triggers immune dysfunction, which is associated with wound healing complications. Gamma-δ T-cells have been shown to be important in postburn inflammation and wound healing; however, their cytokine phenotype at the burn wound site is unknown. C57BL/6 male mice were subjected to a major burn (25% TBSA, third degree) or sham treatment. At 3 hours, 3 days, and 7 days thereafter, skin samples were collected and subjected to dispase and trypsin digestion to isolate single cells. The… CONTINUE READING
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