Burn-induced organ dysfunction: vagus nerve stimulation attenuates organ and serum cytokine levels.

@article{Niederbichler2009BurninducedOD,
  title={Burn-induced organ dysfunction: vagus nerve stimulation attenuates organ and serum cytokine levels.},
  author={A. D. Niederbichler and Stephan Papst and Leif Claassen and Andreas Jokuszies and Lars Steinstraesser and Tobias Hirsch and Mehmet Ali Altintas and Kyros R. Ipaktchi and Kerstin Reimers and Theresia Kraft and Peter M Vogt},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={2009},
  volume={35 6},
  pages={
          783-9
        }
}
INTRODUCTION The interaction of the CNS and the immune system is well known. A parasympathetic anti-inflammatory pathway has recently been described. Both electrical and pharmacological parasympathetic stimulation attenuate proinflammatory mediator generation. Burn induces abacterial cytokine generation and we sought to evaluate whether parasympathetic stimulation after experimental burn decreases cardiodepressive mediator generation. MATERIAL AND METHODS A 30% TBSA full-thickness rat burn… CONTINUE READING

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