Burden of interpandemic influenza in children younger than 5 years: a 25-year prospective study.

@article{Neuzil2002BurdenOI,
  title={Burden of interpandemic influenza in children younger than 5 years: a 25-year prospective study.},
  author={Kathleen M Neuzil and Yuwei Zhu and Marie R. Griffin and Kathryn Margaret Edwards and J. Michael T. Thompson and Sharon J. Tollefson and Peter Farnum Wright},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 2},
  pages={147-52}
}
Many respiratory viruses cause morbidity in young children, but a licensed vaccine and effective oral therapy are available only for influenzavirus. To determine the incidence of laboratory-confirmed influenza illness, we prospectively followed up 1665 healthy children aged <5 years who were enrolled in the Vanderbilt Vaccine Clinic at some point from 1974 through 1999. Viral cultures were obtained when the children presented with clinical illness. The isolation of influenzavirus was associated… CONTINUE READING
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