Burden and pathogenesis of chronic obstructive pulmonary disease.

  title={Burden and pathogenesis of chronic obstructive pulmonary disease.},
  author={Robert Andrew Stockley and David M Mannino and Peter J Barnes},
  journal={Proceedings of the American Thoracic Society},
  volume={6 6},
The burden of chronic obstructive pulmonary disease (COPD) is rising, incurring a major health care burden worldwide. There is no specific therapy other than smoking cessation, which is only partially successful. The condition is recognized to be the result of abnormal control of the inflammatory response to known risk factors, although the exact mechanisms have yet to be identified. However alpha(1)-antitrypsin deficiency represents a human model of all the components of COPD (especially… CONTINUE READING