Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

@article{Kotloff2013BurdenAA,
  title={Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study},
  author={Karen L Kotloff and James P Nataro and William C Blackwelder and Dilruba Nasrin and Tamer H. Farag and Sandra Panchalingam and Yukun Wu and Samba Ousmane Sow and Dipika Sur and Robert F Breiman and Abu S G Faruque and Anita K. M. Zaidi and Debasish Saha and Pedro Lu{\'i}s Alonso and Boubou Tamboura and Doh Sanogo and Uma U. Onwuchekwa and Byomkesh Manna and Thandavarayan Ramamurthy and Suman Kanungo and John B. Ochieng and Richard Omore and Joseph O. Oundo and Anowar Hossain and Sumon Kumar Das and Shahnawaz Ahmed and Shahida M. Qureshi and Farheen Quadri and Richard Adegbola and Martin Antonio and M Jahangir Hossain and Adebayo Akinsola and In{\'a}cio Mandomando and Tacilta Nhampossa and Sozinho Ac{\'a}cio and Kousick Biswas and Ciara E. O’Reilly and Eric Daniel Mintz and Lynette Y. Berkeley and Khitam Muhsen and Halvor Sommerfelt and Roy M Robins-Browne and Myron M. Levine},
  journal={The Lancet},
  year={2013},
  volume={382},
  pages={209-222}
}
BACKGROUND Diarrhoeal diseases cause illness and death among children younger than 5 years in low-income countries. We designed the Global Enteric Multicenter Study (GEMS) to identify the aetiology and population-based burden of paediatric diarrhoeal disease in sub-Saharan Africa and south Asia. METHODS The GEMS is a 3-year, prospective, age-stratified, matched case-control study of moderate-to-severe diarrhoea in children aged 0-59 months residing in censused populations at four sites in… Expand
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The clinical and epidemiological methods used to conduct the Global Enteric Multicenter Study (GEMS), a 3-year, prospective, age-stratified, case/control study to estimate the population-based burden, microbiologic etiology, and adverse clinical consequences of acute moderate-to-severe diarrhea among a censused population of children seeking care at health centers in sub-Saharan Africa and South Asia, are described. Expand
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