Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb.

@article{Wood2006Bur1Bur2AT,
  title={Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb.},
  author={Adam L. Wood and Ali Shilatifard},
  journal={Cell cycle},
  year={2006},
  volume={5 10},
  pages={1066-8}
}
Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are… CONTINUE READING