Bupropion attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.

@article{Lin2013BupropionAK,
  title={Bupropion attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.},
  author={Kao-chang Lin and Chia-Chuan Wang and Su-jane Wang},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2013},
  volume={45},
  pages={207-14}
}
Excessive release of glutamate is believed to be a major component of cell damage following excitotoxicity associated with epilepsy. Bupropion, an atypical antidepressant, has been shown to inhibit glutamate release from rat cerebrocortical nerve terminals. The present study was undertaken to investigate whether bupropion has anti-seizure and anti-excitotoxic effects by using a kainic acid (KA) rat seizure model, an animal model for temporal lobe epilepsy and excitotoxic neurodegeneration. Our… CONTINUE READING
6 Extracted Citations
46 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 46 references

Protective effect of topiramate on kainic acid-induced cell death in mice hippocampus

  • HJ Park, HJ Kin, J Ra, LT Zheng, SV Yim
  • Epilepsia
  • 2008
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…