Bupropion SR worsens mood during marijuana withdrawal in humans

  title={Bupropion SR worsens mood during marijuana withdrawal in humans},
  author={Margaret Haney and Amie S. Ward and Sandra D. Comer and Carl L. Hart and Richard W. Foltin and Marian W. Fischman},
Rationale: Symptoms of withdrawal after daily marijuana smoking include increased ratings of irritability and depression. Similar mood symptoms are reported by cigarette smokers during nicotine abstinence. Objective: Given the successful use of sustained-release bupropion in treating nicotine dependence, this study investigated how maintenance on bupropion influenced symptoms of marijuana withdrawal compared to maintenance on placebo. Methods: Marijuana smokers (n=10) were maintained outpatient… CONTINUE READING