Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.

@article{Rush2006BupropionSRSO,
  title={Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.},
  author={A. Rush and M. Trivedi and S. Wisniewski and J. Stewart and A. Nierenberg and M. Thase and L. Ritz and M. Biggs and D. Warden and J. Luther and K. Shores-Wilson and G. Niederehe and M. Fava},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 12},
  pages={
          1231-42
        }
}
BACKGROUND After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switching to another. METHODS We randomly assigned 727 adult outpatients with a nonpsychotic major depressive disorder who had no remission of symptoms or could not tolerate the SSRI citalopram to receive one of the following drugs for up to 14 weeks: sustained-release bupropion (239 patients) at a maximal… Expand
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