Bupropion “Abuse” Reported to US Poison Centers

@article{Stassinos2016BupropionR,
  title={Bupropion “Abuse” Reported to US Poison Centers},
  author={Gina L Stassinos and Wendy Klein-Schwartz},
  journal={Journal of Addiction Medicine},
  year={2016},
  volume={10},
  pages={357–362}
}
Objectives:Bupropion use to obtain nonmedical psychoactive effects has been reported. The objective was to determine the prevalence, characteristics, clinical effects, and outcomes of bupropion “abuse.” Methods:A 14-year retrospective review was conducted of single substance bupropion cases with “intentional abuse” as the coded reason for exposure in individuals 13 and older reported to the National Poison Data System. Data were evaluated for prevalence, demographics, clinical effect, route… 
Clinical characteristics and outcomes associated with bupropion overdose: a Canadian perspective
TLDR
Patients were less likely to experience a seizure if they had co-ingested benzodiazepines, and the dose of bupropion ingested was significantly associated with the odds of seizure, with a 13% increased likelihood of seizure for every 20 mg/kg increase in bupropions dose.
Characterization of intentional-abuse venlafaxine exposures reported to poison control centers in the United States
TLDR
The prevalence of venlafaxine abuse reported to poison control centers has decreased and Clinicians should be aware that non-medical use is possible but infrequently reported to poisoning control centers.
Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity
TLDR
A retrospective analysis of data collected by the Toxicology Investigators Consortium (ToxIC), a prospective multi-center toxico-surveillance and research network registry, from 2014 to 2017 suggests bupropion may be an atypical cause of serotonin toxicity.
Pediatric Bupropion Ingestions in Adolescents vs. Younger Children—a Tale of Two Populations
TLDR
Adolescents are much more likely than younger children to reach the pre-defined composite endpoint of seizure, hypotension, or need for endotracheal intubation, but this was largely driven by the seizures.
Is There a Potential of Misuse for Venlafaxine and Bupropion?
TLDR
The dopaminergic, stimulant-like, bupropion activities may be associated with its possible recreational value and present data may confirm that the occurrence of a withdrawal syndrome may be a significant issue for venlafaxine-treated patients.
Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine.
Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential
TLDR
While buPropion demonstrates some potential for misuse, pharmacological differences from other structurally-related stimulants limit bupropion’s reinforcing effects.
...
1
2
3
...

References

SHOWING 1-10 OF 31 REFERENCES
An 11-year review of bupropion insufflation exposures in adults reported to the California Poison Control System
TLDR
The abuse of bupropion by crushing and insufflating through the nose is uncommon compared with that by oral buPropion exposures reported to the California Poison Control System and the incidence of seizures appear to be rare.
Bupropion injection resulting in tissue necrosis and psychosis: previously undocumented complications of intravenous bupropion use disorder.
TLDR
A need for policy on clinical strategies to minimize the abuse and diversion of bupropion and other uncontrolled prescription drugs is identified.
Recreational bupropion abuse in a teenager.
  • J. McCormick
  • Medicine, Psychology
    British journal of clinical pharmacology
  • 2002
TLDR
A 13-year old Caucasian girl with a past history of deliberate illicit drug ingestion and evidence of a conduct disorder and mood upset symptoms was admitted to the paediatric ward after intentionally swallowing four bupropion tablets that were supplied by a friend.
Incidence and onset of delayed seizures after overdoses of extended-release bupropion.
Seizures induced by recreational abuse of bupropion tablets via nasal insufflation.
TLDR
The case of a patient with a recent history of generalized tonic-clonic seizures whose etiology was initially a diagnostic mystery, who presented to the emergency department with a recurrence of the seizures after crushing and nasally insufflating oral bupropion tablets is reported.
Intravenous bupropion: a previously undocumented method of abuse of a commonly prescribed antidepressant agent.
TLDR
It is proposed that bupropion may have stimulant effects amenable to abuse that vary with route of administration, and health care providers may wish to exercise additional caution when prescribing buPropion to unfamiliar patients.
Intravenous Administration and Abuse of Bupropion: A Case Report and a Review of the Literature
TLDR
Another case of intravenous administration of and dependence on buPropion in a 29-year-old woman with a history of polysubstance dependence is presented, who consumed an extremely high daily dose of about 2400 mg of bupropion together with a daily oral dose of 2400 to 3600 mg of pregabalin.
Bupropion Diversion and Misuse in the Correctional Facility
TLDR
It is concluded that in the incarcerated population, bupropion is a medication with significant misuse and diversion potential.
Abuse and misuse of antidepressants
TLDR
The majority of individuals prescribed antidepressants do not misuse the medication, however, certain classes of antidepressants do carry abuse potential and Physicians should include antidepressants when screening for risky prescription medication use.
Possible Addiction Transference From Cocaine Insufflation to Oral Bupropion in Bipolar Patient
TLDR
This case is the first case in the literature and emphasizes the risk of bupropion's misuse and physicians should carefully examine the patient's profile before prescribing it, as well as follow appropriate measures.
...
1
2
3
4
...