Buprenorphine versus methadone maintenance therapy: a randomized double-blind trial with 405 opioid-dependent patients.


AIMS To assess the efficacy of buprenorphine compared with methadone maintenance therapy for opioid dependence in a large sample using a flexible dosing regime and the marketed buprenorphine tablet. DESIGN Patients were randomized to receive buprenorphine or methadone over a 13-week treatment period in a double-blind, double-dummy trial. SETTING Three… (More)


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