Buprenorphine suppresses heroin use by heroin addicts.

  title={Buprenorphine suppresses heroin use by heroin addicts.},
  author={Nancy K. Mello and Jack H. Mendelson},
  volume={207 4431},
Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on a clinical research ward where they could acquire heroin (21 to 40.5 milligrams per day, intravenously). Buprenorphine significantly (P less than .001) suppressed the self-administration of heroin over 10 days. Control subjects took between 93 and 100 percent of the available heroin. The effects of buprenorphine were dose-dependent; a dose of 8 milligrams per day… CONTINUE READING