Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.

@article{Mattick2014BuprenorphineMV,
  title={Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.},
  author={Richard P. Mattick and Courtney L Breen and Jo Kimber and Marina Davoli},
  journal={The Cochrane database of systematic reviews},
  year={2014},
  volume={2},
  pages={
          CD002207
        }
}
BACKGROUND Buprenorphine maintenance treatment has been evaluated in randomised controlled trials against placebo medication, and separately as an alternative to methadone for management of opioid dependence. OBJECTIVES To evaluate buprenorphine maintenance compared to placebo and to methadone maintenance in the management of opioid dependence, including its ability to retain people in treatment, suppress illicit drug use, reduce criminal activity, and mortality. SEARCH METHODS We searched… 

Buprenorphine for managing opioid withdrawal.

Buprenorphine was associated with a lower average withdrawal score (indicating less severe withdrawal) during the treatment episode, with an effect size that is considered to be small to moderate, compared to clonidine or lofexidine.

Slow-release oral morphine as maintenance therapy for opioid dependence.

The present review did not identify sufficient evidence to assess the effectiveness of SROM for opioid maintenance because only three studies meeting the inclusion criteria have been identified.

Maintenance treatments for opiate -dependent adolescents.

There is an urgent need for further randomised controlled trials comparing maintenance treatment with detoxification treatment or psychosocial treatment alone before carrying out studies that compare different pharmacological maintenance treatments.

Medication-AssistedTreatmentWith Buprenorphine:AssessingtheEvidence

BMT is associated with improved outcomes compared with placebo for individuals and pregnant women with opioid use disorders and should be considered for inclusion as a covered benefit, according to available research.

Pharmacological therapies for maintenance treatments of opium dependence.

To evaluate the effectiveness and safety of various pharmacological therapies on maintenance of opium dependence compared to no intervention, detoxification, different doses of the same intervention, other pharmacologic interventions and any psychosocial interventions, a systematic review of the literature is lacking.

Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Canada

The effectiveness of buprenorphine/naloxone vs methadone will be determined using intention-to-treat and per-protocol analyses—the former emulating flexible-dose trials and the latter focusing on the comparison of the two medication regimens offered at the optimal dose.

Opioid agonist treatment for people who are dependent on pharmaceutical opioids.

The effects of maintenance opioid agonist pharmacotherapy for the treatment of pharmaceutical opioid dependence is assessed and low-certainty evidence from four studies favouring maintenance buprenorphine treatment over non-opioid treatments in terms of fewer opioid positive urine drug tests at end of treatment is found.

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders.

Low-quality evidence is found that DHC may be no more effective than other commonly used pharmacological interventions in reducing illicit opiate use and other health-related outcomes among adults compared to other drugs or placebos used for detoxification or substitution therapy.

Buprenorphine treatment of opioid dependence: analysis of individual patient data

In a large cohort of trial participants treated with buprenorphine and behavioral counseling for opioid dependence, four novel treatment factors reflecting components of bupenorphine dose, clinical provider engagement and patient engagement are identified and ranked.

Effect of Buprenorphine Dose on Treatment Outcome

Strong evidence exists based on 21 randomized clinical trials that the higher buprenorphine dose may improve retention in bupRenorphine maintenance treatment.
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