Buprenorphine-induced alterations of cocaine's reinforcing effects in rhesus monkey: a dose-response analysis.

@article{Lukas1995BuprenorphineinducedAO,
  title={Buprenorphine-induced alterations of cocaine's reinforcing effects in rhesus monkey: a dose-response analysis.},
  author={Scott E. Lukas and Nancy K. Mello and John Drieze and Jack H. Mendelson},
  journal={Drug and alcohol dependence},
  year={1995},
  volume={40 1},
  pages={87-98}
}
Buprenorphine reduces cocaine self-administration by rhesus monkeys, opiate- and cocaine-dependent men and polydrug abusers, but the mechanisms underlying these cocaine-opiate interactions are not well understood. In the present study, the effects of daily placebo or buprenorphine (0.1, 0.3 and 1.0 mg/kg) treatment on cocaine self-administration (0.001-0.3 mg/kg/inject) were examined in five cocaine-experienced rhesus monkeys. Saline and each of six cocaine doses were available in an irregular… CONTINUE READING

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