Buprenorphine effects on plasma luteinizing hormone and prolactin in male heroin addicts.


Buprenorphine, a mixed opiate agonist-antagonist, suppressed plasma luteinizing hormone (LH) and increased prolactin levels after 12 consecutive days of ascending dose administration (0.5-8 mg/day s.c.) in comparison to drug-free control conditions. During a subsequent 10-day period of buprenorphine maintenance at a dose of a 8 mg s.c., LH levels remained… (More)