Buprenorphine does not aggravate ischemic neuronal injury in experimental focal cerebral ischemia.

Buprenorphine has been increasingly used as maintenance therapy in opioid dependence as an alternative to methadone and other pharmacological therapies. However, available data suggest increased risk of cerebrovascular events in opioid-dependent patients. Therefore, an opioid that provides safety with regard to neurological function should be considered by… CONTINUE READING