Buprenorphine and naloxone for heroin dependence.

  title={Buprenorphine and naloxone for heroin dependence.},
  author={Rolley E. Johnson and Jane McCagh},
  journal={Current psychiatry reports},
  volume={2 6},
The pharmacology of buprenorphine is unique because of its partial agonist profile at the mu-opioid receptor (ie, high affinity, low intrinsic activity and slow dissociation). This unique profile results in greater safety, less physical dependence, and greater flexibility in dose scheduling. Buprenorphine has been investigated in combination with the opioid antagonist, naloxone, with the goal of decreasing abuse, misuse, and diversion. When combined with naloxone in a sublingual tablet… CONTINUE READING