Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations
@article{Coe2019BuprenorphinePR, title={Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations}, author={Marion A. Coe and M. Lofwall and S. Walsh}, journal={Journal of Addiction Medicine}, year={2019}, volume={13}, pages={93–103} }
&NA; Buprenorphine is an effective treatment for opioid use disorder. As a high-affinity, partial agonist for the mu-opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. Other pharmacologic benefits of buprenorphine are its superior safety profile compared with full opioid agonists and its long half-life that allows daily or less-than-daily dosing. New and innovative… CONTINUE READING
Topics from this paper
17 Citations
Optimal dose of buprenorphine in opioid use disorder treatment: a review of pharmacodynamic and efficacy data
- Medicine
- Drug development and industrial pharmacy
- 2020
- 3
- Highly Influenced
Novel Long-Acting Buprenorphine Medications for Opioid Dependence: Current Update.
- Medicine
- Pharmacopsychiatry
- 2020
Buprenorphine implants: a model for expedited development and approval of new drugs.
- Medicine
- Current medical research and opinion
- 2020
Treating Perioperative and Acute Pain in Patients on Buprenorphine: Narrative Literature Review and Practice Recommendations
- Medicine
- Journal of General Internal Medicine
- 2020
Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting
- Medicine
- Journal of addiction medicine
- 2020
- 2
- Highly Influenced
Intravenous Buprenorphine Micro-dosing Induction in a Patient on Methadone Treatment: A Case Report
- Medicine
- Psychosomatics
- 2020
Maternal buprenorphine treatment during pregnancy and maternal physiology.
- Medicine
- Drug and alcohol dependence
- 2019
Diagnosis and Management of Opioid Use Disorder in Hospitalized Patients.
- Medicine
- The Medical clinics of North America
- 2020
References
SHOWING 1-10 OF 49 REFERENCES
Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence.
- Medicine
- Clinical pharmacokinetics
- 2005
- 208
Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.
- Psychology, Medicine
- Archives of general psychiatry
- 1978
- 720
Sustained-Release Buprenorphine (RBP-6000) Blocks the Effects of Opioid Challenge With Hydromorphone in Subjects With Opioid Use Disorder
- Medicine
- Journal of clinical psychopharmacology
- 2016
- 37
Pharmacokinetics and pharmacodynamics of a buprenorphine subcutaneous depot formulation (CAM2038) for once-weekly dosing in patients with opioid use disorder.
- Medicine
- Journal of substance abuse treatment
- 2017
- 16
Effect of Buprenorphine Weekly Depot (CAM2038) and Hydromorphone Blockade in Individuals With Opioid Use Disorder: A Randomized Clinical Trial
- Medicine
- JAMA psychiatry
- 2017
- 31
Pharmacokinetics of Buprenorphine: A Comparison of Sublingual Tablet Versus Liquid after Chronic Dosing
- Medicine
- Journal of addiction medicine
- 2007
- 9
Buprenorphine: new pharmacological aspects.
- Medicine
- International journal of clinical practice. Supplement
- 2003
- 89
Buprenorphine: a (relatively) new treatment for opioid dependence.
- Medicine
- Psychiatry (Edgmont (Pa. : Township))
- 2005
- 25
Human pharmacokinetics of intravenous, sublingual, and buccal buprenorphine.
- Medicine
- Journal of analytical toxicology
- 1996
- 221
- PDF
Buprenorphine implants for treatment of opioid dependence: a randomized controlled trial.
- Medicine
- JAMA
- 2010
- 119
- Highly Influential
- PDF