Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations

  title={Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations},
  author={Marion A. Coe and M. Lofwall and S. Walsh},
  journal={Journal of Addiction Medicine},
  • Marion A. Coe, M. Lofwall, S. Walsh
  • Published 2019
  • Medicine
  • Journal of Addiction Medicine
  • &NA; Buprenorphine is an effective treatment for opioid use disorder. As a high-affinity, partial agonist for the mu-opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. Other pharmacologic benefits of buprenorphine are its superior safety profile compared with full opioid agonists and its long half-life that allows daily or less-than-daily dosing. New and innovative… CONTINUE READING
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