Buprenorphine: differential interaction with opiate receptor subtypes in vivo.

  title={Buprenorphine: differential interaction with opiate receptor subtypes in vivo.},
  author={Wolfgang Sadee and Jan S. Rosenbaum and A. Herz},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={223 1},
The mixed agonist-antagonist buprenorphine previously was shown to display a bell-shaped dose-response curve with peak agonistic (antinociceptive) opiate effects at approximately 0.5 mg/kg s.c., 60 min after the dose and a gradual decline of the effects in the dosage range between 0.5 to 10 mg/kg (electrically induced vocalization test). In vitro, buprenorphine as well as the potent pure agonist etorphine possessed very high affinity for all of the opiate receptor subtypes that are labeled by… CONTINUE READING

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