Buprenorphine/Naloxone

@article{Orman2012BuprenorphineNaloxone,
  title={Buprenorphine/Naloxone},
  author={Jennifer S. Orman and Gillian M. Keating},
  journal={Drugs},
  year={2012},
  volume={69},
  pages={577-607}
}
SummaryAbstractBuprenorphine/naloxone (Suboxone®) comprises the partial μ-opioid receptor agonist buprenorphine in combination with the opioid antagonist naloxone in a 4: 1 ratio. When buprenorphine/naloxone is taken sublingually as prescribed, the naloxone exerts no clinically significant effect, leaving the opioid agonist effects of buprenorphine to predominate. However, when buprenorphine/naloxone is parenterally administered in patients physically dependent on full agonist opioids, the… 

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TLDR
Intramuscular injection of buprenorphine/naloxone precipitates withdrawal in opioid dependent persons; therefore, the combination has a low abuse potential by the injection route in this population.

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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