author={Jennifer S. Orman and G. Keating},
  • Jennifer S. Orman, G. Keating
  • Published 2012
  • Medicine
  • Drugs
  • SummaryAbstractBuprenorphine/naloxone (Suboxone®) comprises the partial μ-opioid receptor agonist buprenorphine in combination with the opioid antagonist naloxone in a 4: 1 ratio. When buprenorphine/naloxone is taken sublingually as prescribed, the naloxone exerts no clinically significant effect, leaving the opioid agonist effects of buprenorphine to predominate. However, when buprenorphine/naloxone is parenterally administered in patients physically dependent on full agonist opioids, the… CONTINUE READING
    67 Citations
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    Effects of buprenorphine and naloxone in morphine-stabilized opioid addicts.
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    Buprenorphine's physical dependence potential: antagonist-precipitated withdrawal in humans.
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    Buprenorphine and naloxone alone and in combination in opioid-dependent humans
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