Bupivacaine uncouples the mitochondrial oxidative phosphorylation, inhibits respiratory chain complexes I and III and enhances ROS production: results of a study on cell cultures.

@article{Cela2010BupivacaineUT,
  title={Bupivacaine uncouples the mitochondrial oxidative phosphorylation, inhibits respiratory chain complexes I and III and enhances ROS production: results of a study on cell cultures.},
  author={Olga Cela and Claudia Piccoli and Rosella Scrima and Giovanni Quarato and Alessandra Marolla and Gilda Cinnella and Michele Dambrosio and Nazzareno Capitanio},
  journal={Mitochondrion},
  year={2010},
  volume={10 5},
  pages={
          487-96
        }
}
This study aimed to validate, in situ, proposed mechanisms of bupivacaine cytotoxicity pointing to impairment of the mitochondrial oxidative metabolism. High resolution oxymetry, carried out on a panel of cell cultures, revealed a dual dose- and time-dependent effect of bupivacaine consisting of uncoupling of the mt Delta mu(H+)-controlled respiratory rates in a cyclosporine A-insensitive manner and further inhibition of the respiratory rates. Intriguingly, a relatively small decrease on the mt… CONTINUE READING
Highly Cited
This paper has 38 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations