Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors.

Fumi Yanagidate, Gary R. Strichartz
Published 2006 in Anesthesiology

Abstract

BACKGROUND Central terminals of primary nociceptors release neurotransmitters glutamate and substance P, which bind to ionotropic or metabotropic receptors on spinal neurons to induce cellular responses. Extracellular signal-regulated kinases are activated by these receptors and are important modulators of pain at the dorsal horn. The authors investigated… (More)

Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1

Mushtaq Ahmad Beigh, Mehvish Showkat, Basharat Bashir, Asma Bashir, Mahboob ul Hussain, Khurshid Iqbal Andrabi
BioMed research international
2014

Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors.

Abstract

Topics

9 Figures and Tables

Cited By

Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1

Pain Relief in Neuropathic Pain-a Comparison between 0.5% Bupivacaine and 0.5% Bupivacaine Streptomycin Combination

Evidence of presynaptic and postsynaptic action of local anesthetics in rats.

Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons

Bupivacaine--the deadly friend of intervertebral disc cells?

Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways

MAP kinase and pain.

[Effect of local anesthetics on the postoperative inflammatory response].

c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?

Novel ideas of local anaesthetic actions on various ion channels to ameliorate postoperative pain.

References

Differential effects of bupivacaine and tetracaine on capsaicin-induced currents in dorsal root ganglion neurons.

Cell signaling and the genesis of neuropathic pain.

Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain

Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics.

Vanilloid receptor 1 regulates multiple calcium compartments and contributes to Ca2+-induced Ca2+ release in sensory neurons.

Local anaesthetics have different mechanisms and sites of action at the recombinant N-methyl-D-aspartate (NMDA) receptors.

The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors.

The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn.

Functional Expression of AMPA Receptors on Central Terminals of Rat Dorsal Root Ganglion Neurons and Presynaptic Inhibition of Glutamate Release

Slides referencing similar topics

Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors.

Abstract

Topics

9 Figures and Tables

Cited By

Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1

Pain Relief in Neuropathic Pain-a Comparison between 0.5% Bupivacaine and 0.5% Bupivacaine Streptomycin Combination

Evidence of presynaptic and postsynaptic action of local anesthetics in rats.

Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons

Bupivacaine--the deadly friend of intervertebral disc cells?

Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways

MAP kinase and pain.

[Effect of local anesthetics on the postoperative inflammatory response].

c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?

Novel ideas of local anaesthetic actions on various ion channels to ameliorate postoperative pain.

References

Differential effects of bupivacaine and tetracaine on capsaicin-induced currents in dorsal root ganglion neurons.

Cell signaling and the genesis of neuropathic pain.

Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain

Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics.

Vanilloid receptor 1 regulates multiple calcium compartments and contributes to Ca2+-induced Ca2+ release in sensory neurons.

Local anaesthetics have different mechanisms and sites of action at the recombinant N-methyl-D-aspartate (NMDA) receptors.

The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors.

The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn.

Functional Expression of AMPA Receptors on Central Terminals of Rat Dorsal Root Ganglion Neurons and Presynaptic Inhibition of Glutamate Release

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