Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice

@inproceedings{Mueller2015BuparvaquoneIA,
  title={Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice},
  author={Joachim Mueller and Adriana Aguado-Mart{\'i}nez and Vera Manser and Vreni Balmer and Pablo Winzer and Dominic Ritler and Isabel Hostettler and David Arranz-Sol{\'i}s and Lu{\'i}s Miguel Ortega-Mora and Andrew Hemphill},
  booktitle={International journal for parasitology. Drugs and drug resistance},
  year={2015}
}
The naphthoquinone buparvaquone is currently the only drug used against theileriosis. Here, the effects of buparvaquone were investigated in vitro and in an experimental mouse model for Neospora caninum infection. In 4-day proliferation assays, buparvaquone efficiently inhibited N. caninum tachyzoite replication (IC50 = 4.9 nM; IC100 = 100 nM). However, in… CONTINUE READING