Bunina bodies in amyotrophic lateral sclerosis

  title={Bunina bodies in amyotrophic lateral sclerosis},
  author={K. Okamoto and Y. Mizuno and Y. Fujita},
  • K. Okamoto, Y. Mizuno, Y. Fujita
  • Published 2008
  • Biology, Medicine
  • Neuropathology
  • Bunina bodies, which are small eosinophilic intraneuronal inclusions in the remaining lower motor neurons, are generally considered to be a specific pathologic hallmark of amyotrophic lateral sclerosis (ALS). One year before a publication by Bunina, van Reeth et al. described similar intracytoplasmic inclusions in the anterior horn cells in a patient with Pick's dementia with atypical ALS. At present, only two proteins have been shown to be present in Bunina bodies, one is cystatin C and the… CONTINUE READING
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