Bunina bodies in amyotrophic lateral sclerosis

@article{Okamoto2008BuninaBI,
  title={Bunina bodies in amyotrophic lateral sclerosis},
  author={Koichi Okamoto and Yuji Mizuno and Yukio Fujita},
  journal={Neuropathology},
  year={2008},
  volume={28}
}
Bunina bodies, which are small eosinophilic intraneuronal inclusions in the remaining lower motor neurons, are generally considered to be a specific pathologic hallmark of amyotrophic lateral sclerosis (ALS). One year before a publication by Bunina, van Reeth et al. described similar intracytoplasmic inclusions in the anterior horn cells in a patient with Pick's dementia with atypical ALS. At present, only two proteins have been shown to be present in Bunina bodies, one is cystatin C and the… Expand
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Grand Rounds Vol 10 Pages L6–l9 Speciality: Landmark Case Report Article Type: Case Report Bunina Bodies
In 1961, Van Reeth and colleagues described the presence of intracellular inclusion bodies in the anterior horn cells of a patient with Pick dementia and atypical amyotrophic lateral sclerosis (ALS).Expand
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  • L. Rowland
  • Medicine
  • Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
TLDR
Tat'yana Bunina, a Russian neuropathologist, has been immortalized because she discovered a neuronal inclusion and it was named after her; Bunina bodies and ubiquitinated inclusions have almost equal diagnostic value. Expand
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References

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INTRACYTOPLASMIC INCLUSIONS (BUNINA BODIES) IN AMYOTROPHIC LATERAL SCLEROSIS
TLDR
In an autopsy case of sporadic amyotrophic lateral sclerosis, there were intracytoplasmic eosinophilic inclusions of the Bunina type in motor neurons that seem to be due to deposition of some metabolite, but their nature is still obscure. Expand
Widely distributed Bunina bodies and spheroids in a case of atypical sporadic amyotrophic lateral sclerosis
TLDR
The autopsy findings of an 81-year-old patient with short-course sporadic amyotrophic lateral sclerosis showed a direct connection between axonal swelling and perikaryon was often seen in the facial and hypoglossal nuclei and in the spinal cord. Expand
Bunina bodies in dendrites of patients with amyotrophic lateral sclerosis.
We studied the brains of two cases of amyotrophic lateral sclerosis with dementia. Bunina bodies were found in the motor neurons of cranial nerve nuclei (trigeminal, facial and hypoglossal nerves) asExpand
Ultrastructure of the Bunina bodies in anterior horn cells of amyotrophic lateral sclerosis
TLDR
Light and electron microscopic studies were made on the anterior horn cells in a case of amyotrophic lateral sclerosis and revealed the presence of two types of cytoplasmic inclusions, including Bunina body, which appeared to be originating from endoplasmic reticulum. Expand
Bunina bodies in amyotrophic lateral sclerosis immunostained with rabbit anti-cystatin C serum
TLDR
During immunohistochemical examinations of spinal cords of patients with ALS, it was noted that BBs were positive for anti-cystatin C (CC) serum and may represent an abnormal accumulation of unknown proteinous material associated with the Golgi apparatus. Expand
Selective appearance of Bunina bodies in amyotrophic lateral sclerosis
TLDR
Bunina inclusion bodies were distributed abundantly in the nerve cell cytoplasm of a case of amyotrophic lateral sclerosis on a routine examination, indicating that this inclusion is related to the primary functional disturbance in the motor neurons of ALS. Expand
Eosinophilic cytoplasmic inclusions in sporadic equine motor neuron disease: an electron microscopic study
TLDR
It was concluded that, although the distribution and nature of the lesions in EMND appeared similar to those of human motor neuron disease, none of the equine eosinophilic inclusions duplicated the ultrastructure of Bunina bodies. Expand
Anterior horn cell degeneration and Bunina-type inclusions associated with dementia
TLDR
The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique, and appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria. Expand
Fine Structure of Anterior Horns in Patients Without Amyotrophic Lateral Sclerosis
  • H. Kusaka, A. Hlrano
  • Chemistry, Medicine
  • Journal of neuropathology and experimental neurology
  • 1985
Light and electron microscopic study of the anterior horns in nine patients without amyotrophic lateral sclerosis (ALS) disclosed several features usually described in ALS. Central chromatolysis andExpand
Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity.
TLDR
It is concluded that the presence of ubiquitin-IR inclusions in lower motor neurons represents a characteristic pathological feature of ALS in its various clinical forms. Expand
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