Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies.

@article{Jaffe2012BumpHT,
  title={Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies.},
  author={Andrew E. Jaffe and Peter N. Murakami and Hwajin Lee and Jeffrey T. Leek and M Daniele Fallin and Andrew P. Feinberg and Rafael A. Irizarry},
  journal={International journal of epidemiology},
  year={2012},
  volume={41 1},
  pages={200-9}
}
BACKGROUND During the past 5 years, high-throughput technologies have been successfully used by epidemiology studies, but almost all have focused on sequence variation through genome-wide association studies (GWAS). Today, the study of other genomic events is becoming more common in large-scale epidemiological studies. Many of these, unlike the single-nucleotide polymorphism studied in GWAS, are continuous measures. In this context, the exercise of searching for regions of interest for disease… CONTINUE READING
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