Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy.

  title={Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy.},
  author={Sanaz Eftekhari and Jafar Mehvari Habibabadi and Massoumeh Najafi Ziarani and Seyed Sohrab Hashemi Fesharaki and Marzieh Gharakhani and Hossein Ahari Mostafavi and Mohammad Taghi Joghataei and Nahid Beladimoghadam and Elham Rahimian and Mahmoud Reza Hadjighassem},
  volume={54 1},
Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult… CONTINUE READING
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Epilepsia, 54(1):e9–e12, 2013 doi: 10.1111/j.1528-1167.2012.03654.x

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