Bulk Raman Analysis of Pharmaceutical Tablets

@article{Matousek2006BulkRA,
  title={Bulk Raman Analysis of Pharmaceutical Tablets},
  author={Pavel Matousek and Anthony W. Parker},
  journal={Applied Spectroscopy},
  year={2006},
  volume={60},
  pages={1353 - 1357}
}
We compare and contrast two Raman collection geometries, backscattering and transmission, to identify their potential for monitoring the bulk chemical composition of turbid media. The experiments performed on pharmaceutical tablets confirm the expected strong bias of the backscattering Raman collection towards surface layers of the probed sample. However, this bias is largely absent with the transmission geometry, exhibiting gross insensitivity to the depth of impurities within the sample. The… 

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References

SHOWING 1-10 OF 34 REFERENCES
Subsurface Probing in Diffusely Scattering Media Using Spatially Offset Raman Spectroscopy
TLDR
A simple methodology for the effective retrieval of Raman spectra of subsurface layers in diffusely scattering media, providing an effective noninvasive means of screening for bone degeneration, other skeletal disease diagnosis, and dermatology studies, as well as materials and catalyst research.
Photon Migration in Raman Spectroscopy
TLDR
This work represents the first detailed study of Raman photon migration under time-resolved conditions and a simple analytical model was developed that gives the correct relationship between the Raman and Tyndall decay exponents for isotropic scattering.
Effect of Powder Properties on the Intensity of Raman Scattering by Crystalline Solids
The effect of particle size on Raman intensity has been measured for a number of crystalline solids with a fiber-optic-based Raman spectrometer. Particle sizes ranged from 76 to 605 μm. Materials
Confocal Raman-Spectroscopy: Analytical Approach to Solid Dispersions and Mapping of Drugs
TLDR
Confocal Raman spectroscopy is successfully used to determine the state of ibuprofen in a solid matrix showing equivalence to a physical solution and is a promising tool for observing changes in a formulation due to physicochemical processes.
Inverse Spatially Offset Raman Spectroscopy for Deep Noninvasive Probing of Turbid Media
TLDR
A new type of highly sensitive spatially offset Raman spectroscopy developed for deep noninvasive probing of stratified turbid media is described, enabling on-the-spot tailoring of experimental conditions such as the magnitude and number of spatial offsets to individual samples.
Depth Profiling in Diffusely Scattering Media Using Raman Spectroscopy and Picosecond Kerr Gating
We demonstrate how pulsed laser Raman excitation (∼1 ps) followed by fast optical Kerr gating (∼4 ps) can be used to effectively separate Raman signals originating from different depths in
Composition profiling of seized ecstasy tablets by Raman spectroscopy.
TLDR
This study highlights the fact that simple physical descriptions coupled with active drug content do not in themselves fully characterize the nature of the seized materials and the potential benefits of obtaining highly detailed spectra can indeed translate into information that is not readily available from other methods but would be useful for tracing of drug distribution networks.
Picosecond Time-Resolved Raman Spectroscopy of Solids: Capabilities and Limitations for Fluorescence Rejection and the Influence of Diffuse Reflectance
It has been known for many years that it should be possible to discriminate between Raman and fluorescence phenomena on the basis of their differing temporal responses. However, it is only relatively
...
...