Bulk Raman Analysis of Pharmaceutical Tablets

  title={Bulk Raman Analysis of Pharmaceutical Tablets},
  author={Pavel Matousek and Anthony W. Parker},
  journal={Applied Spectroscopy},
  pages={1353 - 1357}
We compare and contrast two Raman collection geometries, backscattering and transmission, to identify their potential for monitoring the bulk chemical composition of turbid media. The experiments performed on pharmaceutical tablets confirm the expected strong bias of the backscattering Raman collection towards surface layers of the probed sample. However, this bias is largely absent with the transmission geometry, exhibiting gross insensitivity to the depth of impurities within the sample. The… 

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