Bulbectomy Enhances Neurogenesis and Cell Turnover of Primary Olfactory Neurons But Does Not Abolish Carnosine Expression.

@article{Biffo1992BulbectomyEN,
  title={Bulbectomy Enhances Neurogenesis and Cell Turnover of Primary Olfactory Neurons But Does Not Abolish Carnosine Expression.},
  author={Stefano Biffo and Marco Sasso{\`e} Pognetto and Ludovica Verdun Di Cantogno and Isabelle Perroteau and Aldo Fasolo},
  journal={The European journal of neuroscience},
  year={1992},
  volume={4 12},
  pages={1398-1406}
}
Primary olfactory neurons located in the olfactory neuroepithelium project to the ipsilateral olfactory bulb and undergo a continuous process of neurogenesis and differentiation. We describe, in the adult rat, the kinetics of proliferation, differentiation and survival of primary olfactory neurons either in the presence or absence of their target, the olfactory bulb. The experimental design included unilateral bulbectomy, coupled with a single bromodeoxyuridine pulse 35 days after surgery. The… CONTINUE READING