Building the Informatics Infrastructure for Comparative Effectiveness Research (CER): A Review of the Literature

  title={Building the Informatics Infrastructure for Comparative Effectiveness Research (CER): A Review of the Literature},
  author={Marianne Hamilton Lopez and Erin Holve and Indra Neil Sarkar and Courtney Segal},
  journal={Medical Care},
Background:Technological advances in clinical informatics have made large amounts of data accessible and potentially useful for research. As a result, a burgeoning literature addresses efforts to bridge the fields of health services research and biomedical informatics. The Electronic Data Methods Forum review examines peer-reviewed literature at the intersection of comparative effectiveness research and clinical informatics. The authors are specifically interested in characterizing this… 
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While peer-reviewed, US-based DRN data warehouse governance publications have increased, DRN developers and administrators are encouraged to publish information about these programs.
Preparing Electronic Clinical Data for Quality Improvement and Comparative Effectiveness Research: The SCOAP CERTAIN Automation and Validation Project
In semi-automating data abstraction and conducting a rigorous validation, CERTAIN investigators will semi-Automate data collection to conduct QI and CER, while advancing the Learning Healthcare System.
A Harmonized Data Quality Assessment Terminology and Framework for the Secondary Use of Electronic Health Record Data
A consistent, common DQ terminology, organized into a logical framework, is an initial step in enabling data owners and users, patients, and policy makers to evaluate and communicate data quality findings in a well-defined manner with a shared vocabulary.
Building a Common Pediatric Research Terminology for Accelerating Child Health Research
This work presents the current state of terminology harmonization and describes a governance structure and mechanism for coordinating the development of a common pediatric research terminology that links to clinical terminologies and can be used to align existing terminologies.
eGEMs: Pragmatic Publishing to Build a Learning Health System
The Electronic Data Methods (EDM) Forum announces the launch of eGEMs, a new, free, open access, peer-reviewed e-publication that aims to disseminate innovative ideas about how electronic clinical data can be leveraged in comparative effectiveness research (CER), patient-centered outcomes research (PCOR) and quality improvement (QI).
National health information technology priorities for research: A policy and development agenda
9 priorities and recommended actions to be implemented in collaboration with the research and informatics communities for realizing an optimized health information ecosystem for scientific discovery are outlined.
The creation of an integrated health-information platform: building the framework to support personalized medicine.
The over-riding goal of this platform is to improve patient care, with the developed system enabling this by providing each of the major constituents with evidence-based and tailored information at the individual patient level.
Workplace mental health: An international review of guidelines.
Developing a Standardization Algorithm for Categorical Laboratory Tests for Clinical Big Data Research: Retrospective Study
A method called standardization algorithm for laboratory test–categorical result (SALT-C) that can process categorical laboratory data and can be beneficial for clinical big data research by reducing laborious manual standardization efforts.
How the Provenance of Electronic Health Record Data Matters for Research: A Case Example Using System Mapping
System flow mapping is presented as a method to help researchers more fully understand the provenance of their EHR data as it relates to local workflow and two specific examples of how this method can improve data identification, documentation, and processing are provided.


Research Paper: Clinical Research Informatics: Challenges, Opportunities and Definition for an Emerging Domain
CRI has emerged as a distinct discipline that faces multiple challenges and opportunities and the findings presented provide a framework that should help inform next steps to advance this important new discipline.
Evaluating the informatics for integrating biology and the bedside system for clinical research
The i2b2 hive was found to be a useful cohort-selection tool for fulfilling common types of requests for research data, and especially in the estimation of initial cohort sizes.
Automatic de-identification of textual documents in the electronic health record: a review of recent research
A review of recent research in automated de-identification of narrative text documents from the electronic health record finds methods based on dictionaries performed better with PHI that is rarely mentioned in clinical text, but are more difficult to generalize.
Biomedical informatics and translational medicine
  • I. Sarkar
  • Medicine
    Journal of Translational Medicine
  • 2009
It is proposed that biomedical informatics practitioners ("biomedical informaticians") can be essential members of translational medicine teams.
Slim-prim: a biomedical informatics database to promote translational research.
Slim-Prim is an example of utilizing an IDS to improve organizational efficiency and to bridge the gap between laboratory discovery and practice, and encourages collaboration between researchers and clinicians, an essential factor in the development of translational research.
The use of routinely collected computer data for research in primary care: opportunities and challenges.
Routinely collected primary care computer data, aggregated into large databases, is used for audit, quality improvement, health service planning, epidemiological study and research, but gaps exist in the literature about how to find relevant data, select appropriate research methods and ensure that the correct inferences are drawn.
Regulatory and ethical considerations for linking clinical and administrative databases.
Bridging the gap in medical informatics and health services research: workshop results and next steps.
The workshop addressed ways of increasing the pool of persons interested, trained, and experienced in addressing specific areas of synergy between the two fields of medical informatics and health services research.
Research Paper: Exploring the Degree of Concordance of Coded and Textual Data in Answering Clinical Queries from a Clinical Data Repository
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