Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.

@article{Rowland2009BuildingSC,
  title={Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.},
  author={Benjamin D. Rowland and Maurici Brunet Roig and Tatsuya Nishino and Alexander Kurze and Pelin Uluocak and Ajay Mishra and Fr{\'e}d{\'e}ric Beckou{\"e}t and Philippa Underwood and Jean Metson and Richard Imre and Karl Mechtler and Vittorio L. Katis and Kim Nasmyth},
  journal={Molecular cell},
  year={2009},
  volume={33 6},
  pages={
          763-74
        }
}
Cohesin's Smc1, Smc3, and Scc1 subunits form a tripartite ring that entraps sister DNAs. Scc3, Pds5, and Rad61 (Wapl) are regulatory subunits that control this process. We describe here smc3, scc3, pds5, and rad61 mutations that permit yeast cell proliferation and entrapment of sister DNAs by cohesin rings in the absence of Eco1, an acetyl transferase normally essential for establishing sister chromatid cohesion. The smc3 mutations cluster around and include a highly conserved lysine (K113… CONTINUE READING
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