Building bone to reverse osteoporosis and repair fractures.

@article{Khosla2008BuildingBT,
  title={Building bone to reverse osteoporosis and repair fractures.},
  author={Sundeep Khosla and Jennifer J Westendorf and Merry Jo Oursler},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 2},
  pages={421-8}
}
An important, unfilled clinical need is the development of new approaches to improve fracture healing and to treat osteoporosis by increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7 are FDA approved to promote spinal fusion and fracture healing, respectively, and the first FDA-approved anabolic drug for osteoporosis, parathyroid hormone, increases bone mass when administered intermittently but can only be given to patients in the US for two years. As we… CONTINUE READING

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